Extended Data Fig. 5: MAGMA gene-property analysis. | Nature Neuroscience

Extended Data Fig. 5: MAGMA gene-property analysis.

From: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

Extended Data Fig. 5

Bar plot of the –log10(P from one-sided Z-tests) of the point estimate from a generalized least squares regression. The analysis identified that the externalizing GWAS is significantly enriched in brain and pituitary gland tissues (Supplementary Information section 6). Dashed line denotes Bonferroni-corrected significance, adjusted for testing 54 tissues (one-sided P < 9.26 × 10–4). 14 tissues were significantly associated with the externalizing GWAS, including 13 brain related tissues and the pituitary tissue. The results are also report in Supplementary Table 15.

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