Extended Data Fig. 7: The PANTHER overrepresentation test on the upregulated genes in FXS organoid at each stage show enrichment in distinct pathways. | Nature Neuroscience

Extended Data Fig. 7: The PANTHER overrepresentation test on the upregulated genes in FXS organoid at each stage show enrichment in distinct pathways.

From: A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies

Extended Data Fig. 7

The upregulated genes in FXS at a given developmental stage, D28, D56, or D84 show specific pathway enrichment. The upregulated genes at D28 in FXS organoids are enriched in ciliary locomotion of neuron, axoneme assembly, and other synaptogenesis related pathways while the up-regulated genes at D56 in FXS organoids show more relevance to the pathways associated with synaptic function. Interestingly, genes with higher expression in FXS than in control organoids at the more developed D84 are concentrated in DNA replication, cell division and cell cycle pathways. This suggests aberrant developmental manifestation in FXS organoids. The numbers on the bars indicate the two-sided p values by Fisher’s exact test. The p values have been adjusted for multiple testing using Bonferroni correction.

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