Extended Data Fig. 9: The overlap between human fetal brain DEGs and cell type specific DEGs. | Nature Neuroscience

Extended Data Fig. 9: The overlap between human fetal brain DEGs and cell type specific DEGs.

From: A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies

Extended Data Fig. 9

(a) all single cell cluster specific DEGs were compared with human fragile X fetal brain RNAseq DEGs. The highest overlap is marked with an asterisk above the bar. b, PANTHER gene ontology revealed that theyare involved in GABAergic neuron differentiation, forebrain neuron generation and differentiation. Downregulated genes are enriched in regulation of neural precursor cell, neurogenesis and proliferation, cerebral cortex and forebrain development, gliogenesis, and cell differentiation. The numbers on the bars are two-sdied p-values by Fisher’s exact test. The p values have been adjusted for multiple testing using Bonferroni correction.

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