Extended Data Fig. 3: Clustering of mouse brain cells according to single-cell RNA sequencing. | Nature Neuroscience

Extended Data Fig. 3: Clustering of mouse brain cells according to single-cell RNA sequencing.

From: The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Extended Data Fig. 3

a, UMAP plot of 5,611 mouse brain cells. Clusters were annotated according to marker genes for the specific cell types. b, Dot plots of marker genes used for annotation. Gene expression for all 20 clusters is shown as dot plot with the color representing mean gene expression and the diameters showing the percentage of positive cells in the clusters. c-e, mRNA expression patterns of the putative SARS-CoV-2 entry factors Cd209a (c), Cd209c (d), and Tmprss2 (e). There were no Cd209b- or Cd209d-expressing cells. VLMC, vascular and leptomeningeal cells; OPC, oligodendrocyte progenitor cells.

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