Extended Data Fig. 6: Time dependence of NEMO cleavage by Mpro. | Nature Neuroscience

Extended Data Fig. 6: Time dependence of NEMO cleavage by Mpro.

From: The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Extended Data Fig. 6

Cleavage of human NEMO by SARS-CoV-2 Mpro (0, 5, 10, 25 µM) depended on the incubation time. NEMO (with GST tag) or the cleavage products were detected by immunoblotting (representative for at least 6 experiments at different conditions). The red-boxed part of the blot is shown in Fig. 3a.

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