Extended Data Fig. 5: Reduced Aβ deposition inside grafts of Cx3cr1−/−/5xFAD recipient mice.
From: Microglia contribute to the propagation of Aβ into unaffected brain tissue
(a) Fluorescence microscopy of a graft in Cx3cr1+/−/5xFAD (top) and Cx3cr1−/−/5xFAD (bottom) mice immunostained for Aβ (6E10, red; white arrowheads indicate Aβ), and DAPI (blue) at 4 weeks p.i. Scale bar, 100 μm. (b and c) Graphs show mean (± s.e.m.) of (b) microglia density and (c) percentage of Aβ inside the grafts. Each symbol represents one graft from n = 9 Cx3cr1+/−/5xFAD and n = 7 Cx3cr1−/−/5xFAD mice. Significant differences were determined by the two-tailed Mann–Whitney test (**P = 0.009).
