Fig. 1: The vagus nerve responds to sugars and sweeteners.
From: The preference for sugar over sweetener depends on a gut sensor cell
a, In anesthetized wild-type mice, stimuli were perfused through the duodenum from the pylorus to the ligament of Treitz, while electrical activity was recorded from the cervical vagus nerve. b, Vagal responses to intraduodenal stimuli, including baseline (PBS, gray traces), sucrose (300 mM) (N = 10), d-glucose (150 mM) (N = 5), d-fructose (150 mM) (N = 5), α-MGP (150 mM) (N = 8), maltodextrin (8%) (N = 5), sucralose (15 mM) (N = 11), acesulfame K (ace-K) (15 mM) (N = 5) and saccharin (30 mM) (N = 5), are shown. Peak responses and time to peak are quantified in Extended Data Fig. 1a,b. All peak responses except d-fructose were significant compared to baseline using a Kruskal–Wallis test with non-parametric comparisons using the Wilcoxon method. Gray vertical bars indicate infusion, the bold line indicates the mean, and shaded regions indicate s.e.m.
