Extended Data Fig. 10: Enrichment analysis for genes pertaining to synaptic formation, whose regional distribution corresponds to the distribution of aerobic glycolysis in the human brain, as reported by Goyal et al. (2014) (‘aerobic glycolysis genes’).
From: A synergistic core for human brain evolution and cognition
(a,b) PLS1 and PLS2 are significantly enriched for aerobic glycolysis genes. (c) Enrichment for genes related to aerobic glycolysis is also observed using an alternative approach: ridge-regularised PLS regression on the binarised cortical pattern of synergy vs redundancy prevalence. (d,e) Significant enrichment for genes related to aerobic glycolysis in PLS1 and PLS2 is also observed when controlling for spatial autocorrelation using spin-based permutations. (a-e) Statistical significance is assessed via bootstrap resampling of Z-scores; histograms indicate the relative frequency (over 1,000 bootstraps) of the mean Z-score of a random sample of genes of equal size as the aerobic glycolysis genes. Red vertical line: empirical mean Z-score of aerobic glycolysis genes.
