Extended Data Fig. 4: Tomographic rendering of the PANTHOS neuron from a 5xFAD/TRGL mouse brain shown in Fig. 5a. | Nature Neuroscience

Extended Data Fig. 4: Tomographic rendering of the PANTHOS neuron from a 5xFAD/TRGL mouse brain shown in Fig. 5a.

From: Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

Extended Data Fig. 4

Serial z-stacked image (1 μm thick, number z1–z6) showing a flower shape structure of a PANTHOS neuron displaying the strongly fluorescent blebs with tapered necks arising from the perikaryal plasma membrane. The neuron is from the cerebral cortex layer V of 2.7-month-old male 5xFAD/TRGL mice. Scale bar 10 μm. Experiment was repeated 3 times independently with similar results.

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