Extended Data Fig. 9: Specificity analyses of mouse and marmoset scATAC peak clusters. | Nature Neuroscience

Extended Data Fig. 9: Specificity analyses of mouse and marmoset scATAC peak clusters.

From: Temporally divergent regulatory mechanisms govern neuronal diversification and maturation in the mouse and marmoset neocortex

Extended Data Fig. 9

a, Mouse ATAC peak clusters, reproduced from Fig. 4 for ease of reference (left), and correlation with age versus cell type for each cluster (right). b, Mouse ATAC cluster characteristics as in Fig. 4, for each individual cluster, and number of regions per cluster (cluster sizes). Box and midline: 25th, 50th and 75th percentiles; whiskers: 1.5 interquartile range from box. c, Summary of characteristics for each cluster in mouse. Each arm of the plot represents an individual metric (center = low, edge = high). Boxplots as in b. d, Marmoset ATAC peak clusters, reproduced from Fig. 4 for ease of reference (left), and correlation with age versus cell type for each cluster (right). e, Marmoset ATAC cluster characteristics as in Fig. 4, for each individual cluster, and number of regions per cluster (Cluster sizes). Boxplots as in b. f, Summary of characteristics for each cluster in marmoset. Each arm of the plot represents an individual metric (center = low, edge = high). g, Percentage of overlapping ATAC-seq regions for scATAC-seq based clusters for all neuronal cell types (y axis) with genomic features derived from E14.5 whole mouse brain and adult mouse cortex H3K27ac and polymerase 2 ChIP-Seq from ENCODE as well as enhancers defined by CAGE-Seq from the FANTOM5 consortium (x axis), excluding all ATAC-seq regions overlapping with annotated ensemble promoters. h, Previously defined average open chromatin signal for neuronal mouse scATAC clusters (x axis) shown in a across all neuronal cell types and developmental stages assessed (y axis).

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