Extended Data Fig. 5: Fear conditioning with additional trials yielded a negative dopamine response to the fear cues.
From: Dopamine signaling in the nucleus accumbens core mediates latent inhibition
a, Averaged dopamine signal to fear cues during the first two versus last two CS+ trials in a separate group of C57BL6/J mice (n = 4). b, Dopamine response to the CS+ (area under the curve, AUC) following 6 trials of the latent inhibition experiment compared to the dopamine response to the CS+ in an additional group with extensive fear conditioning trials did not differ for the first 6 trials (RM ANOVA group × trial interaction F(2, 14)= 0.52, P = 0.60; main effect of group F(1, 7) = 0.12, P = 0.20) before becoming a negative response after the 9th trial. Data represented as mean ± s.e.m. ns = not significant.
