Extended Data Fig. 8: Enhanced neuronal activation in the aPVT and DMH is suppressed by PLX3397 treatment in mice fed HFD. | Nature Neuroscience

Extended Data Fig. 8: Enhanced neuronal activation in the aPVT and DMH is suppressed by PLX3397 treatment in mice fed HFD.

From: Diet-induced inflammation in the anterior paraventricular thalamus induces compulsive sucrose-seeking

Extended Data Fig. 8

a-d, Representative images (left) and quantification of the number (right) of c-fos+ cells (green) in the aPVT (a), pPVT (b), DMH (c), and VMH (d) in mice from chow (aPVT: n = 12 sections/4 mice; pPVT: n = 12 sections/4 mice; DMH: n = 9 sections/3 mice; VMH: n = 9 sections/3 mice), chow + PLX3397 (aPVT: n = 19 sections/5 mice; pPVT: n = 16 sections/5 mice; DMH: n = 15 sections/5 mice; VMH: n = 11 sections/3 mice), HFD (aPVT: n = 15 sections/4 mice; pPVT: n = 18 sections/5 mice; DMH: n = 15 sections/4 mice; VMH: n = 14 sections/4 mice), and HFD + PLX3397 (aPVT: n = 18 sections/5 mice; pPVT: n = 20 sections/5 mice; DMH: n = 15 sections/4 mice; VMH: n = 12 sections/4 mice) groups. Scale bars, 100 μm. * P < 0.05, *** P < 0.001. Data are mean ± SEM. See Supplementary Table 2 for further details of statistical data analysis.

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