Extended Data Fig. 1: Compulsive eating behavior in HFD mice appears before a greater body weight gain in these mice than in chow mice.
a, Quantification of the numbers of lever presses in the 30-min baseline (BL, solid bars) and 30-min test (open bars) sessions of the sucrose self-administration test in mice fed chow (n = 14 mice) or HFD for 3 days (n = 9 mice), 1 week (1-wk, n = 8 mice), 2 weeks (2-wks, n = 7 mice), 4 weeks (4-wks, n = 10 mice), or 8 weeks (8-wks, n = 11 mice). b, Bar graph showing the ratios of test lever presses to baseline lever presses in animal groups shown in a. BL, baseline. c, Quantification of the body weight of mice fed chow (n = 11 mice), chow + PLX3397 (n = 10 mice), HFD (n = 11 mice), or HFD + PLX3397 (n = 10 mice) in a period of 30 days. d, Bar graphs showing the body weight of mice in c at 7 days (left), 14 days (middle), and 28 days (right) following their respective treatment. e, Quantification of calorie (Kcal) intake of mice fed chow (n = 4 cages, 20 mice), chow + PLX3397 (n = 3 cages, 18 mice), HFD (n = 4 cages, 20 mice), or HFD + PLX3397 (n = 3 cages, 18 mice) for 14 days. * P < 0.05, ** P < 0.01, *** P < 0.001. Data are mean ± SEM. See Supplementary Tables 1 and 2 for further details of statistical data analysis.
