Extended Data Fig. 3: Inactivation of posterolateral OFC does not disrupt flexible memory encoding.
From: A molecularly integrated amygdalo-fronto-striatal network coordinates flexible learning and memory
(a) Left. Chemogenetic receptor expression in the anterior ventrolateral OFC from experiments described in Figs.1–3 of main text. Right. Extent of inhibitory chemogenetic receptor expression in the posterolateral OFC. Anterior-posterior (A-P) distance from bregma noted. (b) Timing of CNO administration for posterolateral OFC inactivation during memory encoding. (c) Responses across training (session: F6,84 = 73.9, p < 0.001; session × virus: F6,84 < 1). (d, e) Responses during first (reinforcement: F1,14 = 8.49, p = 0.011; reinforcement × virus: F1,14 = 1.59, p = 0.228) and second choice tests (reinforcement: F1,14 = 26.9, p < 0.001; reinforcement × virus: F1,14 < 1). Choice tests were performed on sequential days. Data presented as individual points or mean ± S.E.M. *p < 0.05 (main effect). n = 8 GFP, 8 hM4Di mice. Correspondence to main figures noted. Analyses were performed by ANOVA (2-sided) with repeating measures when appropriate; no adjustments for multiple comparisons required.
