Extended Data Fig. 10: Correlations between BLA→OFC→DMS circuit-defined dendritic spine plasticity and choice behavior.
From: A molecularly integrated amygdalo-fronto-striatal network coordinates flexible learning and memory
Correlation between individual choice test preference ratios (reinforced / non-reinforced) and dendritic spine parameters from Fig.6. (a–d) Dendritic spine density for all spines (F1,10 = 5.12, p = 0.047), and by mushroom- (F1,10 = 5.71, p = 0.038), thin- (F1,10 = 1.14, p = 0.311), and stubby-type spines (F1,10 < 1). (e–h) Percent change (trained mouse vs. yoked [∅] cage mate) in dendritic spine density for all spines (F1,10 = 1.43, p = 0.259), and by mushroom- (F1,10 < 1), thin- (F1,10 = 8.79, p = 0.014), and stubby-type spines (F1,10 = 1.10, p = 0.319). (i-j) Mushroom-to-thin spine-type ratio (F1,10 = 4.88, p = 0.052). Percent change (F1,10 = 4.03, p = 0.073). (k, l) Head volume of mushroom-type spines (F1,10 < 1). Percent change (F1,10 = 8.82, p = 0.014). Data presented as individual points. 95% confidence interval (grey shading). *p < 0.05. †p = 0.052. #p = 0.073. Panels g and l reproduced in Fig.6. Centre lines indicate regression.
