Extended Data Fig. 1: Mice do not display preference for one nose-poke aperture during training.
From: A molecularly integrated amygdalo-fronto-striatal network coordinates flexible learning and memory
Response side bias (responses on aperture to be non-reinforced / total responses) during training sessions. (a) BLA→OFC inactivation: memory encoding (session: F14,378 = 1.22, 0.256; session × CNO: F28,378 < 1), (b) delayed memory encoding (session: F10,80 = 3.18, p = 0.002; session × CNO: F10,80 < 1), or (c) memory retrieval (session: F8,128 = 4.86, p < 0.001; session × CNO: F8,128 < 1). (d) BLA→OFC stimulation (session: F14,392 < 1; session × cocaine: F14,392 < 1; session × CNO: F14,392 = 1.30, p = 0.205; session × cocaine × CNO: F14,392 < 1). (e) OFC→DMS inactivation (session: F8,144 = 1.05, p = 0.404; session× CNO: F8,144 = 1.21, p = 0.295). (f) OFC→BLA inactivation (session: F8,112 = 1.04, p = 0.205; session × CNO: F8,112 < 1). (g) OFC memory trace inactivation: novel (session: F6,96 = 1.03, p = 0.414; session × 4OHT: F6,96 = 1.73, p = 0.122) or (h) familiar reinforcement conditions (session: F6,108 < 1; session × 4OHT: F6,108 < 1). (i) BDNF-dependent circuit function: BLA-OFC (session: F6,204 = 1.10 p = 0.365; session × lateralization: F12,204 < 1) or (j) OFC-DMS disconnections (session: F6,138 = 1.44, p = 0.204; session × lateralization: F12,138 < 1). Data presented as individual points (semi-transparent) and group means (solid). Correspondence to main figures noted.
