Extended Data Fig. 5: Microglial phenotypic spectrum during postnatal development. | Nature Neuroscience

Extended Data Fig. 5: Microglial phenotypic spectrum during postnatal development.

From: A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes

Extended Data Fig. 5

a: Sagittal view of analyzed brain regions: olfactory bulb (OB), frontal cortex (FC), dentate gyrus (DG), somatosensory cortex (S1), substantia nigra (SN), cochlear nucleus (CN) and cerebellum (CB). b: Confocal images of GFP+ microglia (green) and cell nuclei (Hoechst, blue) from Cx3cr1+/GFP mice at P7, P15, and P22 for each brain region with zoom-in. Scale bar: 50 μm. c: UMAP plots of MorphOMICs-analyzed microglia from b for females (left) and males (right) at P7, P15, P22, and adults. Separate UMAP for each brain region and sex. Each dot represents a bootstrapped persistence image. nsamples = 500 per condition (see also Methods: Average and bootstrapped persistence images).

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