Extended Data Fig. 6: Microglia phenotypic spectrum in the 5xFAD model of familiar Alzheimer’s neurodegeneration. | Nature Neuroscience

Extended Data Fig. 6: Microglia phenotypic spectrum in the 5xFAD model of familiar Alzheimer’s neurodegeneration.

From: A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes

Extended Data Fig. 6

a: Sagittal view of analyzed brain regions: olfactory bulb (OB), frontal cortex (FC), dentate gyrus (DG), somatosensory cortex (S1), substantia nigra (SN), cochlear nucleus (CN) and cerebellum (CB). b: Confocal images showing immunostained microglia (Iba1, green) and cell nuclei (Hoechst, blue) from the analyzed brain regions in 5xFAD3m and 5xFAD6m (3 and 6 months, respectively) with zoom-in. Scale bar: 50 μm. c: Representative persistence images corresponding to each cluster centroid from Fig. 4b with color-coded process density. Top right corner, representative traced microglia. Subtraction image with highlighted overrepresented processes on the representative microglia.

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