Extended Data Fig. 7: Sexually dimorphic microglia phenotype in 5xFAD. | Nature Neuroscience

Extended Data Fig. 7: Sexually dimorphic microglia phenotype in 5xFAD.

From: A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes

Extended Data Fig. 7

a: Palantir reconstruction of microglial morphological trajectory in males (top) and females (bottom). Each time-point highlighted in a separate Palantir plot. b: Palantir reconstruction of microglial trajectory with corresponding color-coded CD68 fold change next to it for females (left) and males (right) in control adult, 5xFAD3m, and 5xFAD6m of OB, SN, CN, and CB. Fold change: blue < 0; red > 0. Olfactory bulb (OB), frontal cortex (FC), dentate gyrus (DG), somatosensory cortex (S1), substantia nigra (SN), cochlear nucleus (CN), and cerebellum (CB). nsamples = 500 per condition (see also Methods: Average and bootstrapped persistence images).

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