Extended Data Fig. 8: Microglia phenotypic spectrum in the CK-p25 model of sporadic neurodegeneration. | Nature Neuroscience

Extended Data Fig. 8: Microglia phenotypic spectrum in the CK-p25 model of sporadic neurodegeneration.

From: A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes

Extended Data Fig. 8

a: Sagittal view of analyzed brain regions: olfactory bulb (OB), frontal cortex (FC), dentate gyrus (DG), somatosensory cortex (S1), substantia nigra (SN), cochlear nucleus (CN) and cerebellum (CB). b: Confocal images showing stained microglia (Iba1, green) and cell nuclei (Hoechst, blue) from analyzed brain regions and CK-p251w, CK-p252w, CK-p256w mice (1-, 2- and 6-weeks after doxycycline withdrawal) with zoom-in. Scale bar: 50 μm. c: Representative persistence images corresponding to each cluster centroid from Fig. 5b with color-coded process density. Top right corner, representative traced microglia. Subtraction image with highlighted overrepresented processes on the representative microglia.

Back to article page