Extended Data Fig. 9: Sexually dimorphic microglial phenotype in CK-p25. | Nature Neuroscience

Extended Data Fig. 9: Sexually dimorphic microglial phenotype in CK-p25.

From: A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes

Extended Data Fig. 9

a: Palantir reconstruction of microglial morphological trajectory in males (top) and females (bottom) in control and CK-p25 mice. Each disease time-point highlighted in a separate Palantir plot. b: Monocle reconstruction of microglia trajectory of females (left) and males (right) in control, adult and CK-p25 mice FC, DG, and S1. c-d: Palantir reconstruction of microglia trajectory and corresponding color-coded CD68 fold-change of females (left) and males (right) for SN, OB (c) and CN, CB (d). Fold change: blue < 0; red > 0. nsamples = 500 per condition (see also Methods: Average and bootstrapped persistence images).

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