Fig. 3: Microglial phenotypes during postnatal development.
a, Timeline of postnatal brain development with highlighted events. Sagittal view of analyzed brain regions. b–d, UMAP plots of MorphOMICs-analyzed microglia across seven brain regions in Cx3cr1-GFP+/− mice at P7, P15, P22 and adults (b), and color-coded brain regions for both sexes (c) and for each sex independently with dashed lines as the reference for each developmental time point (d). e, Palantir reconstruction of microglia morphological trajectory from d with P7, P15, P22 and adults highlighted for each brain region. Nearby points indicate similar persistence images. Each dot represents a bootstrapped persistence image. nsamples = 500 per condition (‘Average and bootstrapped persistence images’).
