Extended Data Fig. 8: Transformation of thalamic sound tuning profiles between wakefulness and anesthesia.
From: Awake perception is associated with dedicated neuronal assemblies in the cerebral cortex
a, Left panel: a fragment of response profile correlation matrix containing 2800 of 13314 clustered responsive thalamo-cortical terminals (7 mice) recorded in the layer 1 of the auditory cortex in the awake state. Middle panel: Response probability for thalamo-cortical terminals organized with the same clustering as for the matrix of the left panel (colors in the upper band indicate the type of sound). Right panel: Mean response profiles of thalamo-cortical terminals in the awake state (green trace) and under anesthesia (black trace) for the 3 sample clusters labeled in the left panel. Error bands indicate standard deviation around the mean. As for the cortical neurons, tuning profiles of thalamo-cortical fibers are significantly modified (red rectangles underneath the traces indicate a significant difference; two-sided Wilcoxon rank sum test, using a p-value threshold of 0.05) when changing from the awake to anesthetized state. (AM, Amplitude modulated sounds; Pure, Pure tones; Resp. proba., Response probability). Error bands indicate standard deviation around the mean. b, Same as a for another fragment of the same correlation matrix, now containing 620 of 13314 responsive thalamo-cortical terminals.
