Fig. 7: Specificity of cortical neurons for evoked or ongoing activity is redistributed in anesthesia.
From: Awake perception is associated with dedicated neuronal assemblies in the cerebral cortex
a, Plot of the probability of being recruited in an ongoing event (spont. prob.) plotted against the probability of responding to any sound (evoked prob.) for 3,641 neurons in 5 mice in the awake state (left) and under anesthesia (right). The color code is defined as in the left panel. Under anesthesia, the three color-coded populations converge to a single group with strongly correlated probability of activation in spontaneous and evoked events. b, Top: time course of the mean firing rate profiles in the awake state (left) and under anesthesia (right) for each of the three groups of neurons defined in a for the awake state. Bottom: same as above but when the responsive, spontaneous and nonspecific groups are defined in anesthesia. Error bands indicate the s.d. around the mean. c, Top: same as a but probabilities reshuffled along each axis to show the expected probability distribution for independent participations in ongoing and evoked events. Bottom: corresponding distribution of probabilities difference (ongoing − evoked, 6,310 neurons, in 11 mice). Experimental is black and reshuffled dark khaki. d, Probability distributions for 6,310 surrogate neurons with equal participation probabilities in ongoing and evoked events. e, Probability distributions for 6,310 surrogate neurons with probabilities of participating in spontaneous and evoked activity correlated but not equal (that is, the difference between spontaneous and evoked probabilities is drawn from a continuous Gaussian distribution). Exp., experimental; ISO, isoflurane anesthesia; Nonsp., nonspecific; reshuf., reshuffled; Resp., responsive; Spont., spontaneous.
