Extended Data Fig. 10: Effects of S1/S2, cALM, and ThalALM photoinhibition on ALM activity.
From: Thalamus-driven functional populations in frontal cortex support decision-making
a Spike rates during photoinhibition (1.3 s) versus control conditions. Filled circles, ALM neurons that are significantly modulated by photoinhibition (defined as P < 0.01 using a two-tailed t-test between photoinhibition and control trials). Left column, all neurons. Right column, neurons that retained >50% of the control condition spike rate during photoinhibition. b Effects of photoinhibition on ALM stimulus mode. Activity modes are computed using only neurons that retained >50% of control condition spike rate during photoinhibition. Mean ± SEM (bootstrap, Methods). Dotted lines show activity projections of control trials. Dashed lines delineate behavioral epochs. The effects are similar to Fig. 7. c Same as (b) but for ALM choice mode. Mean ± SEM (bootstrap, Methods). d Same as (b) but for ALM ramping mode. Mean ± SEM (bootstrap, Methods). e Example ALM neurons during ThalALM photoinhibition. Spike raster and PSTH. Left, control trials; middle, sample epoch photoinhibition; right, delay epoch photoinhibition. Cyan bars, photostimulation period. Neurons are not silenced by ThalALM photoinhibition, but lost selectivity.
