Fig. 4: ALM receives long-range inputs from S1/S2, cALM and ThalALM which are required for behavior.
From: Thalamus-driven functional populations in frontal cortex support decision-making
a, Retrograde and anterograde tracing from ALM. Left: labeling in ipsilateral S1/S2, cALM and ipsilateral ThalALM. Right: magnified images. Red, retrograde labeling (WGA-Alexa594); green, anterograde labeling (GFP); blue, Nissl stain. Retrograde and anterograde tracings were performed in the same brain. This experiment was repeated in five mice with similar results. b, Behavioral performance in the tactile decision task with photoinhibition of left S1/S2 (top), right ALM (middle) or left ThalALM (bottom) during different trial epochs. Thick lines, mean; thin lines, individual mice (S1/S2, n = 6; cALM n = 4; ThalALM, n = 5). S1/S2, *P = 0.012; cALM, **P = 0.0016; ThalALM, *P = 0.015, ***P = 0.0001; P values obtained by nested bootstrap across mice, sessions and trials, one-sided test (Methods). Ctrl, control.
