Fig. 7: Activity modes coding stimulus and choice require thalamic inputs.
From: Thalamus-driven functional populations in frontal cortex support decision-making
a, Effects of photoinhibiting S1/S2 (top), cALM (middle) and ThalALM (bottom) on ALM stimulus mode. Mean ± s.e.m. (bootstrap, Methods). Dotted lines, activity in control trials. Dashed lines delineate behavioral epochs. Both correct and error trials are included in activity projections, grouped by instructed trial type. Blue, ‘lick right’ trials; red, ‘lick left’ trials. b, Same as a but for ALM choice mode. Mean ± s.e.m. (bootstrap, Methods). c, Same as a but for ALM ramping mode. Mean ± s.e.m. (bootstrap, Methods). d, Changes in ALM activity modes during photoinhibition relative to control trials. Activity changes in ‘lick left’ and ‘lick right’ trials are averaged. Data from sample and delay epoch photoinhibition are combined. Only neurons with more than five error trials and at least two photoinhibition trials for each trial type are included (S1/S2, n = 326; cALM, n = 310; ThalALM, n = 208). Box and whisker plot shows median, 25/75th percentiles and most extreme data points not considered as outliers. ThalALM versus S1/S2, P = 0.039, 0.001, 0.11, <1 × 10−4, 0.003, 0.025, 0.011 for stimulus, choice, action, outcome, ramping, go, response modes, respectively; ThalALM versus cALM, P = 0.065, 0.016, 0.059, 0.003, 0.005, 0.098, 0.019. P values obtained by bootstrap, one-sided test (Methods).
