Fig. 8: Action mode and movement initiation require thalamic inputs.
From: Thalamus-driven functional populations in frontal cortex support decision-making
a, Direct photoinhibition of ThalALM using GtACR1. Injection of AAV Cre virus in a Cre-dependent GtACR1 reporter mouse. Red, expression of GtACR1 in ThalALM. This experiment was repeated in seven mice with similar results. b, Effect of photoinhibiting ThalALM on ALM action mode. Dotted lines, activity in control trials. Dashed lines delineate behavioral epochs. Correct, error and ignore trials are combined, grouped by instructed trial type. Blue, ‘lick right’ trials; red, ‘lick left’ trials. Photostimulation power, 1–3 mW. c, Left: lick rate in control and ThalALM photoinhibition trials (n = 5 mice). Right: fraction of ignore trials in control and ThalALM photoinhibition trials. Thick lines, mean; thin lines, individual mice. ***P < 1 × 10−4; P value obtained by nested bootstrap across mice, sessions and trials, one-sided test (Methods).
