Fig. 4: The sparsification function of abDGCs is restricted to a transient period of their maturation.
From: Adult-born dentate granule cells promote hippocampal population sparsity
a, Triple-(DG-CA3-CA1) ensemble recording with 5-ms blue-light delivery in abDGC::ChR2 mice at 9–12 wpi. b, ChR2-eYFP-expressing abDGCs at 9.5 wpi. DG granule cell nuclei stained with NeuN. Representative image from four mice. Scale bar, 100 µm. c, Estimation plot showing sparsity of PC population vectors before (gray) versus immediately following (purple) optogenetic activation of 9–12-week-old abDGCs. Each data point represents the mean sparsity for one recording session (n = 43 sessions in 3 mice). Upper and lower plots as in Fig. 1f. d, Group mean change in Z-scored instantaneous firing rate for the PC populations recorded in DG, CA3 and CA1 of abDGC::ChR2 mice, w.r.t. abDGC activation during 4–7 versus 9–12 wpi.
