Extended Data Fig. 7: Multiple examples of neuronal nibbling by BG. | Nature Neuroscience

Extended Data Fig. 7: Multiple examples of neuronal nibbling by BG.

From: Synaptic pruning through glial synapse engulfment upon motor learning

Extended Data Fig. 7

Multiple examples of the nibbling by BG of the pre-synaptic (a-e; blue), the post-synaptic (f-i; orange), and the inhibitory interneurons (j). a-c, Typical examples of empty (a), sparse lamellar (b), and multilamellar (c) phagosomes (arrowheads) and their origins (asterisks). d, Three other representative examples of unknown aberrant organelles (red dashed circles) were frequently observed at the origin of the engulfed protrusions. e, One example of an unknown organelle connected to the expanded ER at the origin of the phagosome. f-i, Typical examples of empty (f), sparse lamellar (g), and multilamellar (h) phagosomes (arrowheads) and their origins (asterisks). i, Examples of aberrant lamellar structures in phagosomes connected to ERs in spines. j, Two other cases of the multilamellar body from herniated mitochondria (purple). All scale bars were 0.5 µm and serial images were taken at 50 nm z-steps. We have done 1 independent experiment.

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