Extended Data Fig. 1: Subhypnotic ketamine impairs sensorimotor processing but not gross animal movement.
From: Ketamine triggers a switch in excitatory neuronal activity across neocortex
(a, b) Duration effect of single dose of ketamine (KET; 50 mg/kg: 20 mice, 100 mg/kg: 11 mice) or saline (11 mice) on time for complete removal of adhesive from snout (TAR) (a) and forelimb withdrawal response to air puff (b). (c) Example images of marble burial test under different conditions. Note that saline-injected mice bury a fraction of marbles over 30 min (middle image). (d) Summary of results of marble burial test for 16 mice in each treatment group. Mice injected with KET at either 50 or 100 mg/kg fail to bury a single marble (example image in c). Number of marbles buried within 30 min was 0 in KET (50 or 100 mg/kg) vs. 4.1 ± 1 in saline-injected mice. One-sided Kruskal-Wallis with Dunn’s multiple comparisons test, P < 0.001. (e) Tracking of total distance and average speed for 14 mice over 5 min period before and after KET at 50 mg/kg in a standard mouse cage. Two-sided Wilcoxon rank test, P > 0.05 for both parameters. Exact P values in figure. Error bars show s.e.m.
