Extended Data Fig. 6: Laser during outcome presentation had no effect on trial initiation latencies or choice in mice expressing EYFP in ACC-DMS neurons.
From: A neural substrate of sex-dependent modulation of motivation
a. Comparisons between shifted inverse gaussian fits from laser and non-laser trials revealed no differences in EYFP-expressing males or females. (2-sided Wilcoxon signed rank tests, females: scale: W = 19, p = 0.09, shape: W = 4, p = 0.22 shift: W = 12, p = 0.84, males: shape: W = 15, p = 0.44, scale: W = 12, p = 0.84, shift: W = 15, p = 0.44, n = 6 females, 6 males; Data is presented as mean ± SEM). b. Trial initiation latencies averaged in quartile bins of relative chosen value (QCh−QU, where QCh and QU are the action values for the chosen and unchosen lever, respectively) for mice expressing EYFP in ACC-DMS neurons. Paired comparisons between laser and non-laser trials were performed for each bin with 2-sided Wilcoxon signed rank tests (Female laser v. no laser bin 1: W = 17, p = 0.22, bin 2: W = 20, p = 0.06, bin 3: W = 6, p = 0.31, bin 4: W = 20, p = 0.06; Male bin 1: W = 16, p = 0.31, bin 2: W = 10, p = 1, bin 3: W = 19, p = 0.09, bin 4: W = 13, p = 0.69; Data is presented as mean ± SEM). c. The probability of making a right choice was averaged in quantile bins of relative side value (QR−QL, where QR and QL are the action values for the right and left lever, respectively) for each animal and averaged. Error bars are SEM.
