Extended Data Fig. 5: SARS-CoV-2 cerebral infection produces cellular apoptosis. | Nature Neuroscience

Extended Data Fig. 5: SARS-CoV-2 cerebral infection produces cellular apoptosis.

From: Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate

Extended Data Fig. 5

a, Light-transmitted images of the indicated cerebral regions from control and SARS-CoV-2 infected K18-hACE2 mice (6 dpi) after c-caspase-3 immunohistochemistry. Images in the right column depict, at higher magnification, the insets of the central column. c-caspase-3 immunostainings were performed in 4 independent experiments obtaining similar results. b, Qualitative analysis of cellular apoptosis, induced by SARS-CoV-2 infection, in different cerebral regions. The table indicates the number of mice showing c-casp3+ cells above the level in control mice among the total number of mice studied for each brain region analyzed.

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