Extended Data Fig. 6: Optogenetic activation of cMPOAEsr1-VMHvl pathway suppresses attack in naive SW males.
From: A hypothalamic pathway that suppresses aggression toward superior opponents
(a) Viral strategy for optogenetic activation of cMPOAEsr1-VMHvl terminals in naive SW males. (b) Experimental timeline. (c,d) Representative raster plots showing attack and investigation toward a male intruder in mCherry control mice aligned to sham (c) and light (d) onsets. (e,f) Representative raster plots from a ChR2 test mouse. (g-j) The stop attack latency (g), attack re-initiation probability (h), attack duration per trial (i), and investigation duration per trial (j) toward a C57 male intruder during sham and light stimulation of mCherry control and ChR2 test SW mice. All data are presented as mean ± s.e.m. n = 6 mice for mCherry group and 7 mice for ChR2 group. Two-way RM ANOVA with Sidak’s multiple comparisons test (g-j); *P < 0.05; **P < 0.01; Otherwise, P > 0.05.
