Extended Data Fig. 1: cMPOA in males show higher aggressor cue-induced c-Fos after defeat.
From: A hypothalamic pathway that suppresses aggression toward superior opponents
(a), Schematic illustration of the experimental procedures. CCC: cup-cup-cup; DDC: defeat-defeat-cup. (b), Schematic illustration of the cup assay performed on the third day. (c), Percentage of time the animal spent in far zone, as illustrated in (b). (d), Percentage of time the animal spent on approaching and investigating the cupped aggressor. (e), Frequency of approach toward the cupped aggressor. (f), Representative images showing c-Fos expressing cells in rMPOA and cMPOA after CCC and DDC tests. Scale bar, 0.5 mm. (g), Quantification of c-Fos-positive cells in the rMPOA and cMPOA in CCC and DDC groups. Four sections were counted for each MPOA sub-region for each animal. All data are presented as mean ± s.e.m. (c–e), n = 4 mice for CCC group, and 5 mice for DDC group. (g), n = 4 mice per group. Two-tailed paired t-test; *P < 0.05; **P < 0.01; Otherwise, P > 0.05.
