Extended Data Fig. 1: Brain vasculature characterization across six brain regions.
From: Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease
a. Markers for vascular cell types (left) and cell subtypes (right). The z-scores are shown at the pseudo-bulk level. The top 5 markers for each cell type or subtype with highest fold change and the known markers are shown along the right side of the heatmap. b-c. UMAPs showing the comparison of brain vascular nuclei in this study (labeled as ‘ROSMAP’) and Yang et al. at both the cell type (b) and subtype (c) levels. d. Heatmaps showing the significant overlap of marker genes at the subtype level between this study (labeled as ‘ROSMAP’) and Yang et al. (top: significance; bottom: the fraction of overlapped genes). The top heatmap shows the fraction of overlapped genes. The -log10(adj. p-value) are shown in the bottom heatmap to represent the significance (Fisher’s exact test, two-sided adjusted p-value < 0.05 as a cutoff). e. UMAPs showing the correspondence of pericyte subtypes between this study and Yang et al. The top UMAP shows the two subtypes of pericytes identified in this study. The bottom two UMAPs show the T-pericyte and M-pericyte signature score distribution in this study. The signature genes of T-pericyte and M-pericyte were defined in Yang et al.
