Fig. 3: Accurate behavioral responses in both populations.
a, The overall response rate across different sleep stages during OFF (blue) and ON (green) stimulation periods in participants without (left) and with (right) narcolepsy. The total number of trials in a given condition is indicated on top of the bars. We used binomial generalized mixed-linear models with participants as a random factor for statistical analysis. All P values are corrected for multiple comparisons using the Benjamini–Hochberg procedure. Response rates were significantly larger in ON than in OFF periods (pairwise post hoc two-sided comparisons) in HP during wakefulness (P < 0.0001), N1 (P < 0.0001), N2 (P < 0.0001), REM (P = 0.0003) and in NP during wakefulness, N1, N2, REM and lucid REM sleep (all P < 0.0001). b, Accuracy was computed over responsive trials in the lexical decision task for participants without narcolepsy—HP (left) and with narcolepsy—NP (right). Only participants with at least three responses were included in this analysis (number of HP: wake = 21, N1 = 17, N2 = 10; number of NP: wake = 24, N1 = 25, N2 = 24, REM = 12, lucid REM = 15). Each dot represents a participant and dashed lines indicate the 50% chance level. The boundaries of the boxes represent the first and third quartiles (Q1 and Q3, respectively), the midline represents the median and the whiskers depict Q1 − 1.5× IQR and Q3 + 1.5× IQR. One-sided Wilcoxon signed-rank test revealed that both HP and NP were significantly more accurate than chance in all tested sleep stages (corresponding P values are indicated in the figure). IQR, interquartile range. ****, P < 0.0001; ***, P < 0.001.
