Fig. 1: Experimental design and rat IVSA cocaine model of addiction. | Nature Neuroscience

Fig. 1: Experimental design and rat IVSA cocaine model of addiction.

From: Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition

Fig. 1

a, Schematic of the study design. b, Timeline of the behavioral protocol. c, Individual differences in total number of cocaine rewards in self-administration (SA), PR and shock-paired (Shock) sessions for each rat. d, Mean AI scores in high and low AI rats. e, Mean number of cocaine rewards across each ShA and LgA IVSA session in high (n = 21) and low (n = 25) AI rats. f, Breakpoint analysis of high (n = 21) and low (n = 25) AI rats under ShA versus LgA (unpaired two-sided Studentʼs t-test with Bonferroni adjusted P = 0.0001; ShA versus LgA for high AI rats, t41 = 4.525). g, Mean number of cocaine rewards when paired with electric footshock in high (n = 21) and low AI (n = 25) rats (P = 0.0003; unpaired two-sided Studentʼs t-test, t44 = 3.936). Error bars in d–g represent s.e.m.

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