Fig. 3: Differential response patterns of MeAFoxp2 and MeADbx1 cells during fighting and mating in socially experienced male mice.
From: Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors
a, Schematics of viral strategies and the fiber photometry setup. b, Experimental timeline for Ca2+ recordings in freely moving experienced male mice. c,f,i–l, Representative Ca2+ traces and PETHs of MeAFoxp2 (c–f) and MeADbx1 (i–l) cells during interactions with an adult male, an adult female, a pup and an object. Dashed black lines in PETHs represent the behavior onset at time 0; blue lines in Ca2+ traces indicate time 0 when the intruder is introduced. g,m, Introduction responses of MeAFoxp2 (g) and MeADbx1 (m) cells, calculated as the peak Ca2+ signal within the first 100 s after stimulus introduction. h,n, Average Ca2+ responses of MeAFoxp2 (h) and MeADbx1 (n) cells during behaviors toward various conspecific intruders and a novel object. o, PIs of MeAFoxp2 and MeADbx1 cells showing the relative introduction response magnitudes across different social stimuli. p, PIs of MeAFoxp2 and MeADbx1 cells showing the relative investigation response magnitudes across different social stimuli. g,h,n–p, Mixed-effects analysis followed by Sidak’s multiple comparisons tests; P < 0.0001 (interaction term). m, Friedman test followed by FDR correction; P = 0.0023. h,n, One-sample t-test with null hypothesis Fz = 0, corrected for repeated testing with FDR of 0.05. Parentheses indicate number of animals. All statistical tests are two-tailed. Data are mean ± s.e.m; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, #q < 0.05, otherwise P > 0.05 and q > 0.05. See Source Data Fig. 3 for more detailed statistics.
