Extended Data Fig. 5: Assessment of proliferation/differentiation ratio in 2-month-old SYNGAP1 haploinsufficient and control organoids. | Nature Neuroscience

Extended Data Fig. 5: Assessment of proliferation/differentiation ratio in 2-month-old SYNGAP1 haploinsufficient and control organoids.

From: Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis

Extended Data Fig. 5

A. Representative single channel images from BrdU pulse-chase experiments in 2-month-old PatientCorrected organoids. Images show the expression of the progenitor marker SOX2, the neuronal marker NeuN and the proliferative marker BrdU. B. Representative single channel images from BrdU pulse-chase experiments in 2-month-old Patientp.Q503X organoids. Images show the expression of the progenitor marker SOX2, the neuronal marker NeuN and the proliferative marker BrdU. C. Representative single channel images from BrdU pulse-chase experiments in 2-month-old 03231Control organoids. Images show the expression of the progenitor marker SOX2, the neuronal marker NeuN and the proliferative marker BrdU. D. Representative single channel images from BrdU pulse-chase experiments in 2-month-old 03231p.Q503X organoids. Images show the expression of the progenitor marker SOX2, the neuronal marker NeuN and the proliferative marker BrdU.

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