Extended Data Fig. 5: Analysis of TFs and regulons in the MN dataset.
From: Molecular blueprints for spinal circuit modules controlling locomotor speed in zebrafish
a, UMAP of three color-coded TF-defined MN clusters (MN-t1-3). The cluster in gray corresponds to the immature MN cluster (MN4). The inset shows whole dataset-defined clusters from Fig. 1. b, Examples of differentially expressed TFs in each TF-defined MN cluster. The size of the circle reflects the proportion of the cells expressing the gene in a cluster (% expressed), and the color intensity reflects its average expression level within that cluster (avg. expressed). c, Plots of highly enriched regulons in cluster MN-t1 (left) and MN-t2 (right). d, Table showing regulons with highest normal enrichment scores (NES) obtained by iRegulon analysis. A high NES ( > 3.0) indicates a potential regulator TF of a subset of target genes sharing specific RNA binding motifs.
