Extended Data Fig. 3: Kinematic analysis for D1 and D2 SPN stimulation experiments.
From: Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice
a, ChR2 stimulation of D1 or D2 SPNs caused rotation accompanied by contraction of the axial (head and trunk) musculature. For D1 SPNs ChR2-induced rotation was contraversive, whereas for D2 SPNs the rotation was ipsiversive. Contraction of axial musculature is interpreted as a change in the head angle relative to the upper body (contraction of the splenius capitis), or as a change in the angle of the upper body relative to the lower body (contraction of trunk musculature, including the abdominal obliques). Representative example from n = 14 fibers implanted in 7 mice from two independent experiments. b, Stimulation of D1 SPNs causes changes in both body and head orientation. Body, ***P = 7.7 × 10−10; head, ***P = 4.5 × 10−4; one-way ANOVA with Tukey’s multiple comparison test; n = 14 fibers implanted in 7 mice (where n is the average of 10 trials for each fiber) from two independent experiments. c, Stimulation of D2 SPNs causes changes in both body and head orientation. Body, ***P = 5.4 × 10−9; head, ***P = 6.4 × 10−4; one-way ANOVA with Tukey’s multiple comparison test; n = 14 fibers implanted in 7 mice (where n is the average of 10 trials for each fiber) from two independent experiments. Data in a-c represent extended analysis of the data presented in Fig. 2c, Extended Data Fig. 2b. Error bands in the time series plots in b and c (top) represent the standard error of the mean. Box-and-whisker plots in b and c give the median, the 25th and 75th percentiles, and the range.
