Extended Data Fig. 5: ChR2 interrogation of the Vgat+ SNr → PnO projection.
From: Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice
a, ChR2 stimulation of Vgat+ SNr neurons caused ipsiversive turning. Body, ***P = 1.8 × 10−4; head, P = 0.43; one-way ANOVA with Tukey’s multiple comparison test; n = 7 mice (where n is the average of 10 trials for each mouse) from two independent experiments. b, The ipsiversive turning phenotype using the strategy in (a) was partly recapitulated by stimulating Vgat+ neurons in SNr that were retrogradely targeted from PnO, Body, ***P = 5.4 × 10−5; head, P = 0.95; one-way ANOVA with Tukey’s multiple comparison test; n = 7 mice (where n is the average of 10 trials for each mouse) from two independent experiments. c, The ipsiversive turning phenotype using the strategy in (a) was partly recapitulated by stimulating Vgat+ SNr terminals in PnO. Body, ***P = 8.3 × 10−5, head, P = 0.98; one-way ANOVA with Tukey’s multiple comparison test; n = 7 mice (where n is the average of 10 trials for each mouse) from two independent experiments. Error bands in the time series plots (top) represent the standard error of the mean. Box-and-whisker plots give the median, the 25th and 75th percentiles, and the range.
