Extended Data Fig. 3: Early NG2 glia depletion accelerates prion disease in male but not female mice. | Nature Neuroscience

Extended Data Fig. 3: Early NG2 glia depletion accelerates prion disease in male but not female mice.

From: NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling

Extended Data Fig. 3

a, Experimental design of NG2 glia depletion in prion inoculated PdgfrαiDTR mice. Littermate Pdgfrα-CreER and iDTR mice were pooled together as control (Ctrl) and treated with tamoxifen and DT the same way as the PdgfrαiDTR mice. b, Survival curves showing accelerated prion disease in male, but not female NG2-glia-depleted (PdgfrαiDTR) mice compared to NG2 glia intact (Ctrl) mice after prion inoculation (median survival: 180 days for male PdgfrαiDTR mice; 187.5 days for male control mice; 174 days for female PdgfrαiDTR mice; 177 days for female control mice). Male mice: n = 8 for Ctrl; n = 9 for PdgfrαiDTR. Female mice: n = 8 for Ctrl; n = 5 for PdgfrαiDTR. Log-rank test: P = 0.0123 for male: P = 0.3571 for female.

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