Extended Data Fig. 4: Single cell RNAseq analyses of cerebellar astrocytes.

(a) Violin plot of the expression of genes used to distinguish Bergmann glia (BG) and velate astrocytes (VA). (b) GSEA plot of enriched key GO pathways in cerebellar astrocyte clusters. (c-f) Top GO pathways altered in Arl13bcKO cerebellar astrocyte clusters. (g) Gene signature expression of pan-reactive, A1-reactive, A2-reactive and Alzheimer’s disease (AD)-associated astrocytes in control and Arl13bcKO cerebellar astrocyte clusters BG_I, BG_II, BG_III, and VA. A2 reactive astrocyte signature is elevated in Arl13bcKO BG_III cluster.