Extended Data Fig. 7: Trajectories of established AD-related proteins. | Nature Neuroscience

Extended Data Fig. 7: Trajectories of established AD-related proteins.

From: Proteomic changes in Alzheimer’s disease associated with progressive Aβ plaque and tau tangle pathologies

Extended Data Fig. 7

a, Box plots of four key AD-related proteins part of the differentially expressed proteins between the different AT categories (A-T-: n = 352; A + T−: n = 184; A + T + : n = 231) and non-AD neurodegenerative diseases (n = 110). Values correspond to residual values after regressing out age, sex and mean overall protein level. In all box plots, the box limits represent the first and third quartile, and the whisker extends to 1.5 time the interquartile range. The red dot represents the mean and the red line extends ±1 standard deviation. b, Proteins shown in panel a plotted against the pseudotime using generalized additive models. Error bands around the data correspond to the 95% confidence interval.

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