Extended Data Fig. 8: Microglia states across the different protein modules. | Nature Neuroscience

Extended Data Fig. 8: Microglia states across the different protein modules.

From: Proteomic changes in Alzheimer’s disease associated with progressive Aβ plaque and tau tangle pathologies

Extended Data Fig. 8

a, Correspondence of different microglial states from human single-cell data from Olah et al, Nature Communications, 2020 (stacked barplots) across the different BioFINDER-2 Proteomic modules (x-axis). For simplicity, all homeostatic states have been grouped together, and clusters 5, 6 and 7 have also been grouped together due to their high similarity as described in Olah et al. b, c, The predominance of microglia-related proteins in Module 2 was also confirmed in comparing two other sets of microglia genes derived from human aged brains: Patrick et al, Translational Psychiatry, 2021 (b) and Olah et al, Nature Communications, 2018 (c). Number of microglial proteins identified from two previous publications (y-axis) across the different Olink modules (x-axis). The number of proteins overlapping between Olink data and each of the three microglia data is reported in the titles.

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