Fig. 2: Differential protein abundance in CSF between AT comparisons. | Nature Neuroscience

Fig. 2: Differential protein abundance in CSF between AT comparisons.

From: Proteomic changes in Alzheimer’s disease associated with progressive Aβ plaque and tau tangle pathologies

Fig. 2

a,b, Volcano plots depicting DAPs in different groups: A−T− (n = 352) versus A+T− (n = 184) (a) and A+T− versus A+T+ (n = 231) (b). Models included age, sex and mean overall protein level as covariates. The red line represents the threshold of PFDR < 0.01, above which we considered proteins for subsequent analyses. Only the top proteins are labeled for legibility on the volcano plots. c, Venn diagram summarizing the comparisons shown in a and b based on proteins significant at PFDR < 0.01 in the main cohort, BioFINDER-2. d, Volcano plots depicting DAPs in BioFINDER-1 (validation cohort, Olink proteomics) between A− (n = 415) and A+ (n = 292) individuals, including age, sex and mean overall protein level as covariates. e, Volcano plots depicting DAPs in ADNI (validation cohort, SomaLogic proteomics) between A− (n = 212) and A+ (n = 215), including age and sex as covariates. Some proteins appear twice given that different aptamers measured the same protein. A− or A+ status was based on Aβ-PET. In d and e, the analysis was restricted to proteins that overlapped with those available in BioFINDER-2 (BF2). All standardized β values displayed come from two-sided linear regressions and all P values were adjusted for FDR.

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