Fig. 4: DAPs related to longitudinal tau-PET. | Nature Neuroscience

Fig. 4: DAPs related to longitudinal tau-PET.

From: Proteomic changes in Alzheimer’s disease associated with progressive Aβ plaque and tau tangle pathologies

Fig. 4

Standardized β coefficients from linear models relating accumulation of AD fibrillar pathology (Aβ- and tau-PET rate of change both included as independent variables) to the CSF protein levels. Models included age, sex and mean overall protein level as covariates. Only proteins with significant associations with tau-PET rate of change are displayed, because there were no associations with Aβ-PET rate of change. The top row included all CU and MCI participants and the bottom row only Aβ-positive CU and MCI participants (as in Fig. 3a). All linear regressions performed were two sided and P values were adjusted for the FDR. *PFDR < 0.05, **PFDR < 0.01, ***PFDR < 0.001.

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