Fig. 6: Biological modules derived from protein co-expression.
a, Bar plots showing the number of proteins in each module derived based on protein co-expression. b, Bar plots showing the distribution of the DAPs in each protein co-expression module. c, Average protein level from each module plotted against the pseudotime using GAMs. d, Summary figure of associations with baseline Aβ- and tau-PET load as well as tau-PET rate of change, cell-type enrichment and summary terms from functional analyses of biological processes for each module. For simplicity, only significant results from two-sided regressions (PFDR < 0.05; P values were adjusted for the FDR) are displayed in colored cells. e, Average protein level from modules 2 and 5 (the two modules containing most DAPs) plotted against Aβ- and tau-PET load (baseline) and tau-PET rate of change (longitudinal) using GAMs. f, Key AD markers along with the average DAPs from modules 2 and 5 plotted against the pseudotime using GAMs. The tau tangles were measured from tau-PET SUVR in a temporal meta-ROI, Aβ and phosphorylated tau were measured, respectively, from Elecsys CSF Aβ40/Aβ42 and p-tau181, atrophy was measured from cortical thickness in the temporal lobe and cognition was measured from the MMSE total score. In all panels, error bands around the data correspond to the 95% CI.
